Exposure to vape and e-cigarette residue on surfaces while pregnant could be putting unborn babies at risk of immune system damage, new research in mice suggests.
Exposure to vape and e-cigarette residue on surfaces while pregnant could be putting unborn babies at risk of immune system damage, new research in mice suggests.
From the article: Exposure to vape and e-cigarette residue on surfaces while pregnant could be put unborn babies at risk of immune system damage, new research suggests.
Vape liquid contains propylene glycol, glycerol, and often nicotine, flavors, and other additives. When heated it can produce toxic chemicals like formaldehyde, acetaldehyde, and acrolein, a hazardous air pollutant.
“When vapes are used indoors, or in a vehicle, the vapour condenses on surfaces forming a thick, oily layer, and this residue can be absorbed through the skin,” said study co-author Distinguished Professor Brian Oliver, from the University of Technology Sydney (UTS) and the Woolcock Institute of Medical Research.
“Previous research has shown that vaping during pregnancy can cause serious harm to the baby, including increased risk of stillbirth, low birth weight and developmental problems,” he said.
In a new study, led by Dr Chantal Donovan and Dr Richard Kim from the UTS School of Life Sciences, pregnant mice were exposed to e-cigarette vapour residue on towels. Their offspring were then infected with flu, and their immune system response assessed.
The researchers found that in the exposed offspring, a specialised type of immune cell, called a CD8+ T cell, became dysregulated. CD8+ T cells are essential for mounting an effective immune response against infections, as well as cancer.
[The study](https://doi.org/10.1152/ajplung.00078.2024) ‘Maternal third hand exposure to e-cigarette vapor alters lung and bone marrow immune cell responses in offspring in the absence or presence of influenza infection’ has just been published in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
meisha555 on
The full study is locked so only going off of the abstract and attached synopsis.
Need to know how much nicotine based solution they were exposed to in comparison to how much a pregnant mother would be in a residential setting (ie if they are giving the mice 1000x the amount you would ever encounter unless bathing in vape solution).
Does providing them with large amounts of transdermal exposure of this solution activate CD8 cells normally, despite the viral infection. What kind of vape solution was utilized? How many mice were tested? Did they try varying levels of exposure? Did activation of cd8 increase incidence of mortality or extended morbidity? Any recommended changes for future studies to improve on accuracy of results?
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From the article: Exposure to vape and e-cigarette residue on surfaces while pregnant could be put unborn babies at risk of immune system damage, new research suggests.
Vape liquid contains propylene glycol, glycerol, and often nicotine, flavors, and other additives. When heated it can produce toxic chemicals like formaldehyde, acetaldehyde, and acrolein, a hazardous air pollutant.
“When vapes are used indoors, or in a vehicle, the vapour condenses on surfaces forming a thick, oily layer, and this residue can be absorbed through the skin,” said study co-author Distinguished Professor Brian Oliver, from the University of Technology Sydney (UTS) and the Woolcock Institute of Medical Research.
“Previous research has shown that vaping during pregnancy can cause serious harm to the baby, including increased risk of stillbirth, low birth weight and developmental problems,” he said.
In a new study, led by Dr Chantal Donovan and Dr Richard Kim from the UTS School of Life Sciences, pregnant mice were exposed to e-cigarette vapour residue on towels. Their offspring were then infected with flu, and their immune system response assessed.
The researchers found that in the exposed offspring, a specialised type of immune cell, called a CD8+ T cell, became dysregulated. CD8+ T cells are essential for mounting an effective immune response against infections, as well as cancer.
[The study](https://doi.org/10.1152/ajplung.00078.2024) ‘Maternal third hand exposure to e-cigarette vapor alters lung and bone marrow immune cell responses in offspring in the absence or presence of influenza infection’ has just been published in the American Journal of Physiology-Lung Cellular and Molecular Physiology.
The full study is locked so only going off of the abstract and attached synopsis.
Need to know how much nicotine based solution they were exposed to in comparison to how much a pregnant mother would be in a residential setting (ie if they are giving the mice 1000x the amount you would ever encounter unless bathing in vape solution).
Does providing them with large amounts of transdermal exposure of this solution activate CD8 cells normally, despite the viral infection. What kind of vape solution was utilized? How many mice were tested? Did they try varying levels of exposure? Did activation of cd8 increase incidence of mortality or extended morbidity? Any recommended changes for future studies to improve on accuracy of results?