Researchers show that an antidepressant currently on the market and inexpensive, vortioxetine, kills tumour cells in the dreaded glioblastoma – at least in the cell-culture dish
https://ethz.ch/en/news-and-events/eth-news/news/2024/09/antidepressant-shows-promise-for-treating-brain-tumours.html
6 Comments
>The ETH Zurich researchers also used a computer model to test over a million substances for their effectiveness against glioblastomas. They discovered that the joint signalling cascade of neural cells and cancer cells plays a decisive role and explains why some neuroactive drugs work while others don’t.
>
>In the last step, researchers at the University Hospital Zurich tested vortioxetine on mice with a glioblastoma. The drug also showed good efficacy in these trials, especially in combination with the current standard treatment.
>
>The group of ETH Zurich and USZ researchers is now preparing two clinical trials. In one, glioblastoma patients will be treated with vortioxetine in addition to standard treatment (surgery, chemotherapy, radiation). In the other, patients will receive a personalised drug selection, which the researchers will determine for each individual using the pharmacoscopy platform.
Paper: [High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity | Nature Medicine](https://www.nature.com/articles/s41591-024-03224-y)
High concentrations of vitamin C, and/or a handgun, can also kill tissue culture cells.
It’s still pretty expensive in Australia… 5-10 times as much as sertraline
This is the most expensive antidepressant
there was a old anti-gout medication that did the same thing. Whatever happened to that line of research???
I have to warn people, I took this for a couple months. I had super human brain power. But way way overstimulated. I could sprint for 1hr on the treadmill easily. I did so many pushups I cracked my sternum and ended up with costochondritus which was coupled with heart palps by that stage. Still very high anxiety. Very much thought I was having heart attacks. Probably did more damage. My brain went into ultra survival heightened mode and soon little things seemed like threats, which cost me my job. Vortioxetine or brintellix is the devil.