Robust memory of a previous event shown to prevent new flexible memories from being formed, this due to a newly discovered (in mice) neuronal mechanism in the hippocampus

>Researchers at the Dupret laboratory used ‘food-context conditioning’ to train mice over several days to acquire a robust contextual memory by offering them a choice of high fat foods or their normal chow pellets in different environments. They then measured the ability of the mice to continually keep track of objects placed in their environment: remembering old objects and exploring new ones.
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>Results showed the mice with robust memory of a high fat foods failed to distinguish new objects placed in their environment, demonstrating how a robust contextual memory can prevent the formation of new memories. The robust memory recruits a steady amount of nerve cells, a hiring process that later blunts the formation of new flexible memories.
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>The team also highlighted how the diversity of the hippocampal neurons’ population is crucial to the formation of everyday memories, including robust ones. It is the structure of the activity pattern between these neurons that impacts how new information is stored in memory. Dr Giuseppe Gava, commented: ‘We find that overly robust memories, supported by hippocampal neurons synchronising their activity like choristers reciting a melody, are not susceptible to be updated by new information. Like singers too immersed in the melody they’re carrying, they can’t pick up new tunes.’
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>The combination of findings suggests a trade-off between robust and flexible memory computations, explaining why individuals may struggle to adapt their behaviour in certain situations due to strong contextual memories impacting on the present.

Paper: [Organizing the coactivity structure of the hippocampus from robust to flexible memory.](https://www.mrcbndu.ox.ac.uk/publications/organizing-coactivity-structure-hippocampus-robust-flexible-memory)