Synapse-restoring pill set for human trials as novel schizophrenia treatment

https://newatlas.com/medical/synapse-restoring-pill-clinical-trial-schizophrenia/

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  1. TLDR:

    schizophrenia affects how people think, feel and perceive. It presents symptoms like hallucinations, delusions, and disorganized speech,social withdrawal, an inability to feel pleasure (anhedonia), apathy, and lack of emotions, and cognitive symptoms such as problems with memory, attention and reasoning.

    Previous studies have suggested that schizophrenia is associated with a loss of glutaminergic synapses, the main excitatory synapses in the brain that use the amino acid glutamate as a neurotransmitter. (Signals sent across excitatory synapses increase the activity of the receiving neuron; signals sent across inhibitory synapses reduce it.) Through its method of action, SPG302 rapidly regenerates glutaminergic synapses. It’s a completely new approach.

    Billed as a regenerative treatment, SPG302 has the unique ability to restore crucial synapses, the connections through which nerve cells – neurons – communicate.