Psychedelic psilocybin could be similar to standard SSRI antidepressants and offer positive long term effects for depression. Those given psilocybin also reported greater improvements in social functioning and psychological ‘connectedness’, and no loss of sex drive.

https://www.scimex.org/newsfeed/psychedelic-psilocybin-could-offer-positive-long-term-effects-for-depression

7 Comments

  1. I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

    https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00378-X/fulltext

    From the linked article:

    Psychedelic drug psilocybin could be similar to standard SSRI antidepressants in improving depressive symptoms, according to a small study by international researchers who add that psilocybin might even offer additional longer-term benefits. The team undertook a six-month study with 59 patients with moderate-to-severe depression – treating 30 with a single dose of psilocybin, and another 29 with a six-week course of antidepressant escitalopram. Each group was also given psychological support of around 20 hours in total. The team found both groups showed significant improvement in their depressive symptoms, even up to six months after treatment. However, those given psilocybin also reported greater improvements in social functioning and psychological ‘connectedness’, and no loss of sex drive. While better social functioning and connectedness can greatly enhance a person’s quality of life longer-term, the authors warn psilocybin is still an experimental drug, and note these studies are undertaken in highly controlled and protected environments which are not found in recreational drug use.

  2. You see a lot of these posts and never actually hear about it coming to market. What is the timeline on something like this?

  3. I need a big dose of shrooms every 3 months to maintain good mental health, motivation, and habits (like going to the gym and good diet). At the end of the 2nd month, beginning of 3rd month, my time spending at the gym would decrease, and my social media usage and sugar craving would increase. This are good indications I need another dose of shroom.

  4. Hopeful this translates into therapeutic availability soon. My unscientific usage of psilocybin capsules was definitely better than SSRIs, but wasn’t sustainable where I live or at the prices I paid.