Research found that a person’s sex and their unique experiences of childhood trauma can have specific consequences for their biological health and risk of developing 20 major diseases later in life

>The result was two stressor classes for males (High Stress and Low Stress) and three for females (High Stress, Moderate Stress, and Low Stress.) Overall, those in the low-stress classes exhibited the fewest major health issues, with participants’ risk increasing as their stressor exposure increased.
>
>Both males and females in the high-stress classes had the poorest metabolic health and greatest inflammation. However, there were differences between the sexes. The impacts of adverse childhood experiences on metabolic health biomarkers were greater for females than males. Emotional abuse and neglect also tended to have greater effects in males than females for several biomarkers and health conditions such as blood disorders, mental and behavior health issues, and thyroid issues.
>
>Slavich said the findings underscore the need to integrate assessments of stress biology and exposure into clinical care, and to ensure that patients’ risk profiles take sex and specific stressor exposure into account.

Paper: [The effects of childhood adversity on twenty-five disease biomarkers and twenty health conditions in adulthood: Differences by sex and stressor type – ScienceDirect](https://www.sciencedirect.com/science/article/pii/S0889159124004884?via%3Dihub)