Brain goop that traps hunger neurons drives obesity: A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain’s hunger cells.
Brain goop that traps hunger neurons drives obesity: A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain’s hunger cells.
Well, it’s good to know that we now have a method for curing obesity in lab mice. I was starting to worry about them. As for humans? I’m going to guess that injecting Fluorosamine directly into our brains on a regular basis might come with some side effects but, who knows.
SenorSplashdamage on
> As the animals develop insulin resistance, a type of cellular scaffolding, called the extracellular matrix, that holds the hunger neurons in place becomes a disorganized goo. Previously, researchers had noticed that this scaffolding changes when mice are fed a high-fat diet2.
I feel like all of us should approach obesity studies the way we should approach disability studies. It’s very plausible that sometime in our life we could find ourselves experiencing obesity, the same way we’ll personally need assistance for mobility at some point. I see people approach some of the new drugs and research around obesity as an “other people” problem.
I’ve personally always been pretty thin, despite low personal effort to make that the case. With that said, this data points to how someone who had been doing everything right when it came to diet and exercise could still be one lapse away from making a significant and harder to reverse change to how their body even deals with hunger. Someone could have an injury from an accident, end up being less mobile and eating poorly for a season, and then experience a whole different body situation than they did before.
TheGreatSausageKing on
Needs a good way to go, but very interesting to find such a correlation.
there_is_no_spoon1 on
Let’s get human trials started! I’ll volunteer!
DigOnMaNuss on
Is this going to be the new “I’m just big boned”?
Zephirus-eek on
Brain goop? Hunger cells? Sounds legit.
rainbowroobear on
i love how science headlines are on a inverted U curve of undestanderings.
this is the bottom end of simple language, then you’ve got “Pathogenic hypothalamic extracellular matrix promotes metabolic disease” at the other end.
7 Comments
Well, it’s good to know that we now have a method for curing obesity in lab mice. I was starting to worry about them. As for humans? I’m going to guess that injecting Fluorosamine directly into our brains on a regular basis might come with some side effects but, who knows.
> As the animals develop insulin resistance, a type of cellular scaffolding, called the extracellular matrix, that holds the hunger neurons in place becomes a disorganized goo. Previously, researchers had noticed that this scaffolding changes when mice are fed a high-fat diet2.
I feel like all of us should approach obesity studies the way we should approach disability studies. It’s very plausible that sometime in our life we could find ourselves experiencing obesity, the same way we’ll personally need assistance for mobility at some point. I see people approach some of the new drugs and research around obesity as an “other people” problem.
I’ve personally always been pretty thin, despite low personal effort to make that the case. With that said, this data points to how someone who had been doing everything right when it came to diet and exercise could still be one lapse away from making a significant and harder to reverse change to how their body even deals with hunger. Someone could have an injury from an accident, end up being less mobile and eating poorly for a season, and then experience a whole different body situation than they did before.
Needs a good way to go, but very interesting to find such a correlation.
Let’s get human trials started! I’ll volunteer!
Is this going to be the new “I’m just big boned”?
Brain goop? Hunger cells? Sounds legit.
i love how science headlines are on a inverted U curve of undestanderings.
this is the bottom end of simple language, then you’ve got “Pathogenic hypothalamic extracellular matrix promotes metabolic disease” at the other end.